A biotechnology pioneer since 1980, Amgen discovers, develops, manufactures and delivers innovative human therapeutics. Amgen was one of the first companies to realize the new science’s promise by bringing safe, effective medicines from lab to manufacturing plant to patient.   




AT Analytical Inc.
Based in Baltic, South Dakota, AT Analytical provides maintenance and repair service of scientific laboratory instruments and equipment for research facilities and hospitals. The company is an authorized service agent for several manufacturers including Baker, Consolidated Still and Sterilizers, Fisher Scientific and Thermo Fishers, NuAire, Sanyo, Scientek and Tuttnauer, and VWR/Sheldon. 


Augustana College
Founded in 1860, Augustana College in Sioux Falls, S.D., is a selective, residential, comprehensive college of the Lutheran Church. With more than 1,850 students from 25 states and 30 countries, Augustana is featured among “America’s Top Colleges” by Forbes; was ranked among the top 10 baccalaureate colleges in the nation for its efforts to advance social mobility, research and service by Washington Monthly; and has been named a “Best Midwestern College” by The Princeton Review.  


Avera Health
The region’s largest health care system with more than 13,100 employees and gross revenue of nearly $1.8 billion. Avera’s system strength brings exceptional health care to 238 locations in 85 communities of the five-state region. Avera’s inpatient and clinic visits totaled upwards of 2.1 million in the past fiscal year, a number equal to more than twice the population of the Avera service area. 




Bion specializes in the production of analytical standards and reference materials, analytical testing services, proficiency testing programs, laboratory consultation, and quality accreditation services.  


Black Hills State University
Black Hills State University is a master’s level university that promotes excellence in teaching and learning; supports research, creative and scholarly activities and provides service to the state, region, nation and global community. BHSU provides innovative, high quality undergraduate (associate and baccalaureate) programs in the arts, humanities, education, behavioral sciences, mathematics, social sciences, natural sciences, business and technology as well as selected disciplines of strength at the graduate level. Black Hills State University is the only comprehensive University in western South Dakota.


Brookings Economic Development Corporation
Brookings Economic Development Corporation is a private nonprofit 501(c)(6) corporation organized in 1995 as the primary engine for promoting economic growth in Brookings, South Dakota and the surrounding area. The BEDC serves as an advocate for the business community by building relationships with companies that allow them to take advantage of the area’s science and technology infrastructure, optimal business environment, University research resources, high-performance workforce and progressive community.   




Cambridge Technologies
Cambridge Technologies, a company established by Prairie Holdings Group of Worthington, Minnesota operates a production facility in Sioux Center. The company provides ingredients for animal disease prevention and care.


CEGA Innovations
At CEGA Innovations, LLC, we believe that enhanced, affordable technologies can improve patient care and provide a safer workplace for all medical professionals. Our breakthrough technology, the MuV System, is designed to reduce strain on medical professionals and patients. It is the first in a line of CEGA products for improving quality care in the medical industry.


Celgene is a global biopharmaceutical company committed to improving the lives of patients worldwide. At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients. Our vision as a company is to build a major global biopharmaceutical corporation while focusing on the discovery, the development, and the commercialization of products for the treatment of cancer and other severe, immune, inflammatory conditions.



Christiansen Land and Cattle, Ltd.
A founding member of South Dakota Biotech, the Kimball-based business also is a diversified one, with more than 10,000 acres of corn, soybeans and winter wheat along with a large ranching operation with 12 to 18 employees throughout the year. Christiansen Land and Cattle, Ltd. has served the biotech industry by providing livestock management and biosecurity services.

F&B_Logo_Tagline_Website_Color-c.jpg   Fredrikson & Byron

Fredrikson & Byron was founded in Minneapolis in 1948.  Since then, we’ve grown into an international firm of over 280 attorneys in over 35 practice and industry areas, serving clients from seven offices worldwide. We serve a broad variety of publicly and privately held businesses, financial institutions, municipalities, professional corporations, limited liability companies, nonprofits, trade associations, partnerships, and individuals. Clients include new ventures, small and medium-sized companies, family businesses, and national and international companies traded on world stock exchanges.




MedImmune is the worldwide biologics research and development arm of AstraZeneca, a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of small molecule and biologic prescription medicines.  MedImmune is pioneering innovative research and exploring novel pathways across key therapeutic areas, including respiratory, inflammation and autoimmunity; cardiovascular and metabolic disease; oncology; neuroscience; and infection and vaccines.


Medgene Labs
Medgene Labs is an animal health diagnostics and therapeutic development company working with leading researchers and strategic partners in the fields of virology, bacteriology, immunology, and molecular diagnostics. Sources of market-aligned technology concepts include an expanding network of university researchers, regional producers, biotechnology companies, and contract research organizations.


Monsanto Company is a leading global provider of technology-based solutions and agricultural products that improve farm productivity and food quality. Monsanto remains focused on enabling both small-holder and large-scale farmers to produce more from their land while conserving more of the world’s natural resources such as water and energy.




Nanopareil, LLC 
Headquartered in Rapid City, South Dakota, Nanofiber Separations, LLC produces cutting-edge separation media composed of functionalized nanofibers. The product is manufactured from a randomly overlaid mat of electrospun nanofibers, which provide a unique separation medium capable of both size-based as well as adsorptive separation mechanisms. The highly advanced and proprietary formulation provides the opportunity to greatly enhance process efficiencies and economics in the biopharmaceutical, water treatment, desalination, blood products, and air purification industries.




Northern State University
Located in Aberdeen and founded in 1901, Northern State University is a public institution characterized by outstanding instruction, extraordinary community relations, and unparalleled extracurricular opportunities. It has a total undergraduate enrollment of 2,880 and the campus size is 72 acres.  


With manufacturing and R&D facilities in South Dakota, throughout the U.S. and South Korea, Nutraferma® is a leading biotech company. Nutraferma pioneered a cutting edge solid state fermentation process to produce high value proteins and microbials. Nutraferma’s extensive research work has also produced state-of-the-art yeast products, bioactive peptides and phytogenic additives. 


OmegaQuant, LLC
OmegaQuant, LLC is the exclusive provider of the HS-Omega-3 Index®. This novel blood test was developed to measure the level of omega-3 fatty acids (EPA and DHA) in red blood cell membranes. The risk for sudden cardiac death is reduced by up to 90% in individuals with the highest HS-Omega-3 Index®, and there is growing evidence for an association between omega-3 biostatus and other conditions such as dry eye, macular degeneration, dementia, depression, joint health, etc.




POET, one of the world’s largest ethanol producers, is a leader in biorefining through its efficient, vertically integrated approach to production. The 25-year-old company has a production capacity in excess of 1.6 billion gallons of ethanol and 9 billion pounds of high-protein animal feed annually from its network of 27 production facilities. POET also operates a pilot-scale cellulosic bio-ethanol plant, which uses corn cobs, leaves, husk and some stalk as feedstock, and expects to commercialize the process in Emmetsburg, Iowa through its joint venture with Royal DSM.


Prairie AquaTech
Located in Brookings, Prairie AquaTech specializes in new approaches to aquaculture feeds and health supplements and has developed a process that will replace more expensive natural resources that are currently used in the aquaculture feeds market. Operating in a state-of-the-art aquaculture research facility, the company’s research team is optimizing feed and health supplement formulations and conducting feeding trials to produce fish meal replacers that are a lower cost alternative, blend-ready to meet species nutrient requirements and provide immune enhancing characteristics.




Public Affairs Co. (PhRMA)
PhRMA, the Pharmaceutical Research and Manufacturers of America, represents the country’s leading biopharmaceutical researchers and biotechnology companies. The members are committed to finding tomorrow’s cures and treatments for some of the most serious diseases such as Cancer, Alzheimer’s Disease, Cystic Fibrosis and Parkinson’s.  




Research Park at SDSU 
The Research Park at South Dakota State University and Innovation Center are managed by the SDSU Growth Partnership, Ltd. The Board of Directors delivers both unique insight and experience to the management of these entities. Their leadership has placed South Dakota State University in a strong position moving into the future. They understand the importance of how university talent can assist the economic growth of business and industry in the region.


RTI, LLC (RTI) is a leading veterinary contract research organization and microbiology laboratory. Established in 1994, the company provides clientele with quality services and support, with expertise in vaccinology, microbiology, virology, and nutrition. Specializing in biologicals for food animals, RTI’s clients include several Fortune 500 companies, as well as, multi-nationals, mid-size, and start-up biotech firms. With RTI’s diagnostic reagent area, they offer extensive array of monoclonal antibodies for laboratory needs. The company’s research team strives to stay at the forefront of animal heath advances and improvements while demonstrating leadership in the field of veterinary research and biotechnology.


SAB Biotherapeutics, Inc.
SAB Biotherapeutics, Inc. (SAB), is a biopharmaceutical company on the leading edge of innovation, developing natural technologies that have the potential to transform the treatment and prevention of diseases from cancer to Ebola, and diabetes to influenza. SAB’s first-of-its-kind therapeutic production platform holds the promise of treatment of rare conditions, long-term diseases and global pandemic threats.  


Sanford Health
Sanford Health is an integrated health system headquartered in the Dakotas and is now the largest, rural, not-for-profit health care system in the nation with locations in 126 communities in eight states. In addition, Sanford Health is in the process of developing international clinics in Ghana, Israel and Mexico. Sanford Health includes 35 hospitals, 140 clinic locations and 1,360 physicians in 81 specialty areas of medicine. With more than 26,000 employees, Sanford Health is the largest employer in North and South Dakota. 


Sioux Falls Development Foundation
The Sioux Falls Development Foundation works to encourage local business expansion and new business locations in Sioux Falls. By promoting the unique business advantages of a Sioux Falls location and helping innovative firms to network for rapid business growth, the Development Foundation has been particularly helpful to the biotech industry in the area. 



South Dakota Governor's Office of Economic Development (GOED)
The Governor’s Office of Economic Development expands primary job opportunities in South Dakota by retaining existing businesses, fostering new businesses and recruiting out-of-state companies. Efforts are focused on six key industries, including biosciences. We work with local EDCs to expand and diversify the state’s economy, as well as administer a variety of financing programs. 


South Dakota EPSCoR
In 1980, the National Science Foundation (NSF) established the Experimental Program to Stimulate Competitive Research (EPSCoR). The EPSCoR program is designed to assist states to establish a self-sustaining academic research enterprise with the competitive capability that will contribute to the states’ economic viability and development. SD EPSCoR’s mission is to strengthen research and education in science, technology, engineering and mathematics (STEM) across South Dakota to increase science literacy and drive science-based economic development. SD EPSCoR helps build South Dakota’s research infrastructure and increases its capacity to successfully compete for federal funding. 


South Dakota Innovation Partners
South Dakota Innovation Partners, LLC  is an early-stage venture capital firm focused on accelerating science and technology-based economic development, while providing a return on investment to limited partners. The firm’s  objective is to leverage a market inefficiency that exists in the technology commercialization process by applying a disciplined investment approach to early technology evaluation; providing smart, pre-seed capital and early business development expertise; commercializing research-derived technology through start-up company formation; and building sustainable value that will be realized in subsequent capital rounds. 


South Dakota School of Mines and Technology
Founded in 1885, the School of Mines and Technology (SDSMT)was established to meet the growing research needs of the mining industry, led by the Homestake Mine in Lead, South Dakota. The school is now an elite technological university offering 37 baccalaureate, masters, and doctoral degree programs with 2,350 talented and motivated students engaged in challenging and exciting academic programs. Online degrees are available, including professional master’s programs in construction management, engineering management, and mining engineering. SDSMT believes the role of engineers and scientists is crucial to the advancement of society. Graduates design, construct, and operate the most advanced technology to meet today’s complex challenges, such as climate change, bioenergy, mineral extraction and processing, environmental quality, and national defense.


South Dakota State University
South Dakota State University is the state’s largest and most comprehensive university. It is recognized by the Carnegie Foundation for the Advancement of Teaching as a research university/high activity. Enrollment at SDSU is nearly 13,000 students from throughout South Dakota, all 50 states and 52 countries. The university offers 12 Ph.D. programs and two professional doctoral programs. SDSU has a contiguous campus of 272 acres in Brookings and nearly 15,000 acres in seven locations from Buffalo to Beresford for agricultural research and demonstrations. Biotechnology research education programs include agricultural crops, veterinary and biomedical sciences, industrial biotechnology, pharmaceutical sciences, livestock, bioenergy and other fields.


Syngenta is a leading agriculture company helping to improve global food security by enabling millions of farmers to make better use of available resources. 






University of South Dakota
The University of South Dakota has undertaken a multi-year strategic initiative to expand faculty and student research and creativity, increase grant and contract awards, and commercialize research The U. has several research and creative clusters, including the Center for Research & Development of Light-activated Materials, Centers of Biomedical Research Excellence in neuroscience and in cardiovascular, the Center for Detecting Rare Physics Processes at Homestake, Missouri River Institute, and more. New PhD programs have been created to offer USD students exceptional training and mentoring in Materials Chemistry, Computational Science and Statistics (joint with SDSU), Biomedical Engineering (joint with SDSMT), and Political Science. The U continues to expand its capacity to collaborate with industry. Researchers participate in sponsored R&D, and serve as consultants to manufacturing and business partners. An expanding portfolio of innovative technologies is available to collaborators and the U is pleased to work jointly with industry to bring these technologies to market.




USD Discovery District
The USD Discovery District is a resource to help grow companies in South Dakota and connect universities with innovation-driven businesses. The Master Plan envisions a dynamic environment for students, researchers and entrepreneurs developing new innovations. The 80-acre site includes the Graduate Education and Applied Research (GEAR) Center that provides a physical location for both private sector and university research activities, including USD’s Biomedical Engineering Program (BME). At 22,000 square feet, the Center’s specialized research suites, equipment and technical staff support public and private sector research activities. An Aseptic GMP Production and Training Center provides pilot-scale cGMP and BME faculty and students are actively engaged in industry collaborations to advance the frontiers of biomedical science and engineering bring new products to market. 




Veterinary Medical Center
The Veterinary Medical Center, based in Worthington, MN, offers state-of-the-art veterinary services for both large and small animals. The goal of the Veterinary Medical Center is to ensure their clients are equipped with the preventative, diagnostic, and educational tools necessary to ensure top health for their animals. VMC has a reputation for being an early adapter of new technologies, and the practice is dedicated to finding practical solutions to complex animal disease issues. The staff at VMC prides itself on going the extra mile to provide clients with cost-effective and accurate answers.






Zeal Center for Entrepreneurship
The Zeal Center for Entrepreneurship (formerly the SDTBC) was founded in 2002 and established through a partnership initiative between the Sioux Falls Development Foundation and the Sioux Falls Area Chamber of Commerce through Forward Sioux Falls.

Since its inception, Zeal client companies have collectively created more than 728 new jobs with an average salary of $69,000 and secured more than $172 million in equity funding. In addition, entrepreneurs associated with Zeal hold 65 patents with an additional 49 pending. For information go to: