A-OX Welding

MEMBER SINCE 2022

A-OX Welding Supply is a premier specialty gas, industrial gas, and equipment supplier in South Dakota, North Dakota, Minnesota, Iowa, and Nebraska.

Featuring a state-of-the art ISO/IEC 17025:2005 Accredited gas lab and full-service retail locations across the region. Visit www.aoxwelding.com to find out ways that A-OX Welding Supply can facilitate all of your specialty gas, industrial supply, and industrial safety needs.

AdvaMed

AdvaMed, The Advanced Medical Technology Association (AdvaMed), is a trade association that leads the effort to advance medical technology in order to achieve healthier lives and healthier economies around the world. AdvaMed’s membership has reached over 500 members and more than 80 employees with a global presence including Europe, India, China, Brazil, and Japan. AdvaMed’s member companies range from the largest to the smallest medical technology innovators and companies. The Association acts as the common voice for companies producing medical devices, diagnostic products and digital health technologies.

AdvaMed promotes competitive policies that foster the highest ethical standards, appropriate reimbursement, and access to international markets. While the policies advocated by AdvaMed are tailored to the specific issues facing the device and diagnostics industry, the need for strategic government policies is applicable to all the high technology, high value sectors in which America must compete effectively if it is to assure robust economic growth and a high standard of living for the American people.

Amerging Technologies

MEMBER SINCE 2025

At Amerging Technologies, we take immense pride in being at the forefront of the bioprocessing industry for over a decade. With an unwavering commitment to innovation, precision, and customer satisfaction, we have established ourselves as the leading manufacturer of cutting-edge bioprocess equipment. Our journey over the past 11 years has been marked by a relentless pursuit of excellence and a steadfast dedication to elevating biomanufacturing standards.

Amgen

MEMBER SINCE 2009

A biotechnology pioneer since 1980, Amgen discovers, develops, manufactures and delivers innovative human therapeutics. Amgen was one of the first companies to realize the new science's promise by bringing safe, effective medicines from lab to manufacturing plant to patient.

Augustana University

MEMBER SINCE 2011

Founded in 1860, Augustana University in Sioux Falls, S.D., is a selective, residential, comprehensive college of the Evangelical Lutheran Church of America (ELCA). With more than 2,080 (1,749 undergraduate) from 29 states and 36 countries and a student-to-faculty ratio of 12 to 1, most Augustana science students participate in research programs and experiences. Augustana is featured among "America's Top Colleges" by Forbes; was ranked among the top 10 baccalaureate colleges in the nation for its efforts to advance social mobility, research, and service by Washington Monthly; and has been named "Best Midwestern College" by The Princeton Review.

Avera Health

MEMBER SINCE 2007

The Avera Health system has over 18,000 employees and physicians, serving more than 300 locations and 100 communities in a five-state region. Our ministry, our people and our superior value distinguish Avera. We carry on the health care legacy of the Benedictine and Presentation Sisters, delivering care in an environment guided by our values of compassion, hospitality and stewardship.

For more information about Avera, visit Avera.org.

AYA Corporation

STARTUP • 2025

AYA Corporation is a Section 17 federally chartered economic development corporation wholly owned by the Sisseton-Wahpeton Oyate. Headquartered on the Lake Traverse Reservation in Agency Village, South Dakota, we are dedicated to advancing tribal prosperity through strategic business ventures that create sustainable employment opportunities, generate revenue for essential tribal services, and build economic self-sufficiency through diversified enterprises.

Our mission centers on three core principles: Employment and Economic Empowerment, Financial Independence, and Strategic Business Innovation.

B9Creations

End-to-End Additive Manufacturing Solution

B9Creations offers top-of-the-line 3D printing hardware, software, accessories, materials, and customizable solutions that are setting a new industry standard for repeatability, dependability, and ease of use.

Ballard Spahr

STARTUP • 2025

Ballard Spahr's Midwestern footprint includes a dynamic office in Sioux Falls, a burgeoning center for financial services, health care, agribusiness, and technology.

Our South Dakota-based attorneys advise corporations, financial institutions, and individuals on business law, mergers and acquisitions, private client services, litigation, and real estate matters. We expanded into Sioux Falls through our 2018 merger with Lindquist & Vennum, one of the Midwest's premier business law firms.

Our Business and Transactions team represents clients in a range of industries, from agribusiness and renewable energy to financial services, health care, hospitality, and manufacturing. We advise on transactional and regulatory matters, securities and capital raising, real estate, intellectual property, bankruptcy and restructuring, and other business issues.

Bion

MEMBER SINCE 2012

Bion specializes in the production of analytical standards and reference materials, analytical testing services, proficiency testing programs, laboratory consultation, and quality accreditation services.

Brookings Economic Development Corporation

MEMBER SINCE 2007

Brookings Economic Development Corporation is a private nonprofit 501(c)(6) corporation organized in 1995 as the primary engine for promoting economic growth in Brookings, South Dakota and the surrounding area. The BEDC serves as an advocate for the business community by building relationships with companies that allow them to take advantage of the area's science and technology infrastructure, optimal business environment, University research resources, high-performance workforce and progressive community.

C Steinborn Consulting

STARTUP • 2025

C Steinborn Consulting: Data-driven | People-centered | Payer, Provider, Med Device and Health Tech | Leader in Strategy, Product, Health Equity

Cambridge Technologies

Cambridge Technologies is an independent owner-operated custom vaccine company working with veterinarians and livestock producers to provide solutions to animal health problems.

CBH Energetics

Founded in 2012, CBH Energetics was born out of the philosophy that when it comes to our health and bodies, the more we know, the better off we’ll be.

CBH Energetics’s founder, Samantha Stupak, spent four years of her life sick in bed with Lyme disease. Following that experience, she made a commitment to natural health and helping others – particularly those with chronic health issues – find their path to a healthier, more fulfilling life.

With this in mind, she developed an effective system of using bioresonance testing of hair and saliva to identify bioenergetic stressors. Today, we are proud to offer a selection of tests designed to center on specific stressors, as well as a broad range of remedies.

CBS Bio Platforms Inc.

MEMBER SINCE 2021

CBS Bio Platforms Inc. is an innovation-focused company that researches, develops and manufactures a wide range of products used in feed, food, industrial and environmental applications.

The company was established in 1984 and is headquartered in Calgary, Alberta, Canada, with manufacturing and warehouse locations east and west, serving customers internationally.

CEGA Innovations

MEMBER SINCE 2014

CEGA Innovations engages in the ideation, development, manufacturing, and distribution of medical products that are targeted for use through innovative design and business practices. Real Tech. Real Simple.

Cellular Molecular Institute

MEMBER SINCE 2013

Conduct basic and applied research in all cell and molecular biology aspects. To conduct basic and applied research in all aspects of Cell and Molecular biology.

CureIt LifeSci, LLC

STARTUP • 2025

CureIt LifeSci has started to research, design, and develop new micronutrient based products that address known medical conditions. Using plants that can be continuously harvested, we expect to extract a compound, C007, that enriches healthy tissue, eliminates and suppresses senescent (non-productive) cells while increasing the production of healthy cells. The Company believes that our Products will prove to be valuable in the treatment of healthy people, and compromised patients.

Cytion

Cytion: Premier Cell Bank for Authentic Human and Animal Cells
Cytion upholds its reputation as a trusted cell bank. We specialize in high-quality, contamination-free cells from humans and animals, ensuring rigorous quality control and authentication. Renowned for reliability, our cell lines are the go-to choice for researchers needing genetically authentic samples. With Cytion, experience ease and confidence in sourcing authentic cell culture solutions.

Dakota BioWorx

MEMBER SINCE 2021

Hard Work Happens at the Intersection of Science & Creativity
A state-of-the-art space, technical resources, intellectual muscle, inexhaustible creative energy, here they all come together to take your innovation out of the land of conceptual thinking and into the real world bioeconomy. We bring together top minds in biotechnology to offer you complete, holistic support as you work to address some of the world’s most pressing problems.

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Dakota Provisions

MEMBER SINCE 2018

Dakota Provisions™ was founded with a focus on the idea to support family farms. We are backed by 500 years of combined meat production and meat processing experience. With a strong commitment to quality we are dedicated to building a world-class meat processing facility in Huron, South Dakota. Our commitment carries on to delivering the highest quality product to you, our customer. Leading the industry in food safety is our No. 1 objective. The plant employs more than 600 associates and will employ more than 1,000 within five years.

Dakota State University

When you choose DSU, you become a Trojan through and through.

As a Trojan, you’re part of a school that puts you first.

With extraordinary academics, real-life experience, and innovative technology, you’ll receive an education that stands out amongst your peers. Plus, you graduate with a degree that puts quality into your professional career. Learn from professors that are experts in their field. Team up with classmates who have similar interests.

Embark on research journeys that give you dynamic perspectives. Work in state-of-the-art-facilities with the best labs and collaborative spaces around. To top it all off, you’ll have access to the best technology currently available, giving you the ultimate advantage post-graduation. Did we mention that we have a 99% placement rate for our graduates? It’s true. Choose you. Choose DSU.

Elevate Rapid City

MEMBER SINCE 2020

Elevate Rapid City was established in 2019 merging the Chamber of Commerce and Economic Development organizations to lead the economic development and small business efforts in the Black Hills region. We work to elevate the Rapid City region for all with the strong vision of making Rapid City and the Black Hills region the place people want to be.

Elevate Rapid City is committed to promoting business and personal advancement in western South Dakota through a targeted spotlight on jobs, infrastructure, and overall quality of life in and around the Black Hills region and Rapid City metro area.

Together, we strive to embrace the heart and soul of our community through diversified growth and strong professional opportunities advocating the strengths of the Black Hills.

Epolleo Inc.

STARTUP • 2025

Epolleo is a nonprofit biodiversity platform dedicated to preserving microbial diversity through ethical data stewardship, open-access science, and community-powered discovery. Our mission is to support biodiversity research by collecting, validating, and archiving microbial samples from diverse ecosystems. We link biodiversity education, conservation, and innovation through a secure, transparent digital platform that emphasizes the importance of sustainable science education programs. By empowering students, researchers, and citizen scientists to contribute microbial data, we foster a global ecosystem of collaboration that drives advancements in agriculture, health, environmental resilience, and sustainable technologies. Through serialized Diversity Credits, Epolleo ensures traceability, equitable access, and long-term scientific value of each contribution, facilitating environmental innovation funding. We believe that microbes are foundational to life on Earth and that their preservation and responsible exploration are essential for addressing today’s and tomorrow’s most pressing challenges.

Evergreen AquaFarms

STARTUP • 2025

Evergreen Aquafarms is a pioneering venture in urban agriculture, dedicated to transforming how communities grow, access, and engage with food.

We blend sustainable growing practices with innovative community-driven initiatives. Our mission is to cultivate and deliver high-quality produce year-round through aquaponics and deep-winter greenhouse technologies, while fostering a collaborative ecosystem that supports local farmers and empowers consumers.

Fisher Scientific

MEMBER SINCE 2007

Fisher Scientific offers customers convenient access to a complete portfolio of laboratory equipment, chemicals, supplies and services used in scientific research, health care, safety and education markets. A global network of direct sales professionals, industry-specific catalogs, e-commerce capabilities and supply-chain management services enables Fisher Scientific to offer a broad mix of products manufactured by Thermo Fisher Scientific and third parties.

FreelingBio Research Consulting

STARTUP • 2025

FreelingBio offers comprehensive literature synthesis, data analysis, publication, and grant writing services in the fields of biomedical and nutrition sciences.FreelingBio offers comprehensive literature synthesis, data analysis, publication, and grant writing services in the fields of biomedical and nutrition sciences.

Genentech

MEMBER SINCE 2016

Genentech is a leading biotechnology company that discovers, develops, manufactures and commercializes medicines to treat patients with serious or life-threatening medical conditions. We are among the world's leading biotech companies, with multiple products on the market and a promising development pipeline. GlycoScience Research Inc LOGO GlycoScience Research IncOver the last 20+ years, WH Land & Livecstock LLC has have built a flock of genetically selected carriers for the GM1 gangliosidosis trait. GlycoScience Research Inc (GSR), was incorporated to develop a safe, natural source of GM1 for ganglioside research and therapeutic use. Our mission is to produce and promote ovine GM1 ganglioside as a treatment for Huntington's Disease and other neurological diseases.

Gevo

Gevo, Inc. is a renewable chemicals and advanced biofuels company headquartered in unincorporated Douglas County, Colorado in the Denver-Aurora metropolitan area. Gevo operates in the sustainability sector, pursuing a business model based on the Circular Economy concept. The company develops bio-based alternatives to petroleum-based products using a combination of biotechnology and classical chemistry. Gevo uses the GREET model from Argonne National Laboratory as a basis for its measure of sustainability [1] with the goal of producing high-protein animal feed, corn-oil products, energy-dense liquid hydrocarbons. Gevo is focused on converting sustainably grown raw materials, specifically no. 2 dent corn, into high-value protein and isobutanol, a primary building block for renewable hydrocarbons, including sustainable aviation fuel, renewable gasoline, and renewable diesel. Gevo markets these fuels as directly integrable on a “drop in” basis into existing fuel and chemical products.[2] Gevo's investors include Burrill & Company, Khosla Ventures, Lanxess, Osage University Partners, Total, and Virgin Green Fund, among others.

GlaxoSmithKline

GlaxoSmithKline is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together.

We are a focused biopharma company. We prevent and treat disease with specialty medicines, vaccines and general medicines. We focus on the science of the immune system and advanced technologies, investing in four core therapeutic areas - respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale. Our Ahead Together strategy means intervening early to prevent and change the course of disease, helping to protect people and support healthcare systems.

GRAIL

MEMBER SINCE 2019

GRAIL is a healthcare company whose mission is to detect cancer early, when it can be cured. GRAIL is focused on saving lives and improving health by pioneering new technologies for early cancer detection. The company is using the power of next-generation sequencing, population-scale clinical studies, and state-of-the-art computer science and data science to overcome one of medicine’s greatest challenges with Galleri, GRAIL’s multi-cancer early detection blood test. With this proprietary technology, GRAIL is also developing solutions to help accelerate cancer diagnoses, blood-based detection for minimal residual disease, and other post-diagnostic applications. GRAIL, a wholly-owned subsidiary of Illumina, Inc., is headquartered in Menlo Park, California, with locations in Washington, D.C., North Carolina, and the United Kingdom.

Grass Land Analytics

STARTUP • 2024

Grass Land Analytics believes environmental testing in water, soil, and air is essential for safeguarding human health, maintaining ecosystem balance, adhering to regulations, managing resources sustainably, responding to emergencies, raising awareness, supporting scientific research, and taking preventive measures against environmental degradation.
All the integrity of the heartlands.

Hilltop Harvests

Design, develop, and deploy systems to collect and upgrade biogas from deep pit hog barns.

 

Horizon Therapeutics

MEMBER SINCE 2019

At Horizon, we believe science and compassion must work together to transform lives. Our mission to deliver medicines for rare, autoimmune and severe inflammatory diseases and provide compassionate support comes from our strong and simple philosophy to make a meaningful difference for patients and communities in need.

Houdek

MEMBER SINCE 2012

Houdek is in our nature.
Like the soil from which we're named, we are a diverse mixture, comprised of scientists, technicians, innovators, and stewards of nature's fantastic resources.
As Houdek soil brings agricultural food and environmental security to the world, we provide the aquaculture, pet nutrition, and human health markets with rich, plant-based ingredients.

Inanovate

MEMBER SINCE 2017

Inanovate has developed a novel blood-based protein detection platform called the Bio-ID800 that is slated for regulatory 510k clearance in 2023.

This platform enables parallel and simultaneous detection of large number of protein biomarkers in a multi-modal, multiplex format with applications under development for the clinical laboratory space.

Indevric Consulting LLC

Indevric provides consulting services to pharmaceutical and biotech companies specializing in providing regulatory guidance for small to midsize companies. Our consultants are experienced in developing regulatory strategies and leading health authority interactions for clinical and nonclinical development for small molecules, antibodies (monoclonal and bi-specific), antibody-drug conjugates, recombinant proteins, cell and gene therapies, and drug/device combinations.

Innovative Laboratory Systems, Inc.

MEMBER SINCE 2021

Since 1989, we have served clients across the United States from our offices located in Minneapolis, MN; Omaha, NE; and Kansas City, KS. Innovative Laboratory Systems is a full-service laboratory furniture and equipment company. Our ILS specialists and project managers are accessible during every step of the lab planning and construction process. We make it our priority to help plan, design, deliver, and service laboratory furniture and equipment to our customers across the Midwest. We source the majority of our products from US-based manufacturing companies who share our vision for producing highly functional laboratories. These relationships we have built with our product partners allow us to achieve the best possible results for our customers. Building laboratories is our specialty.

JLG Architects

Building communities that thrive and environments that inspire. 100% Employee Owned.
In 1989, JLG Architects emerged in the Midwest as two-person firm founded by Gary Johnson and Lonnie Laffen. With a “Design for Life” approach to architecture, their integrity and vision became the firm’s catalyst for national growth in leadership, peer education, and client connectivity. Today, JLG is a national pacesetter and home to over 160 employee-owners across 10 offices. JLG is proud to be in the country’s top 50 Best Places to Work (Inc. Magazine), and 50 Most Admired Companies (MSN Money).
Through collaborative solutions, nurtured relationships, and environmental stewardship, we take a lifelong approach to design with unified goals at the helm: increase clients’ well-being, brand, bottom line, and sustainability.

Journey Construction

Quality Construction. Inspired Design.
Unparalleled Experience. Exemplary Service.

The Journey Group is a full-service construction group with headquarters in Sioux Falls, S.D., and six divisions offering general, commercial, manufacturing, industrial, civil, residential and asphalt construction services in the Upper Midwest and nationwide.

Kirkwall

STARTUP • 2025

Kirkwall is an operational security software company dedicated to preserving the integrity of the systems that keep critical industries running. Built by former intelligence and national security professionals, Kirkwall helps manufacturers, energy cooperatives, agricultural co-ops, and critical infrastructure operators protect the assets and systems vital to their operations.​

​By unifying real-time sensor data, behavioral analytics, and environmental monitoring into a centralized platform, Kirkwall empowers teams to detect risks early — from equipment failures to environmental threats and human error — and respond proactively before small issues become costly disruptions. Delivering actionable insights, predictive alerts, and rapid notifications, Kirkwall ensures operators have the visibility and confidence to act before downtime, production loss, or asset failure impacts operations.

McGough Construction

MEMBER SINCE 2019

It takes the effort of hundreds and sometimes thousands of people to bring together the vision, expertise and materials to build any structure. McGough is proud of our role in that process – and we’re proud of the results. As a respected general contractor, we bring six generations of experience to prominent, distinctive and complex construction projects. Our people and their expertise in planning, development, construction and facility management power our success.

From new construction to renovation – with world-class architects and trusted subcontractors – McGough has a history of collaboration and partnership that leverages the power of people and the advantage of cross-functional expertise. We have worked in diverse spaces including corporate, industrial, healthcare, institutional, housing, education, worship, performing arts and retail. Whether your project is large or small, start with confidence from the ground up.

Medgene Labs

MEMBER SINCE 2012

Medgene Labs is breaking the paradigms of herd health management via its powerful animal health service ISPRIME. “IS” stands for “Immunological Services.” Immunological refers to the scientific study of the immune system and the application of research and carefully acquired data. Services refers to a relationship between the immunologist, the producer, and the veterinarian involved in animal health. “Prime” refers to the fact that this valuable immunological service is reserved for a community of livestock producers. Using technologies and methods developed by Medgene Labs, effective vaccines are created with extraordinary precision and speed. These vaccines are deployed where and when they're needed through the producer's veterinarian.

MedQ Opportunity

STARTUP • 2025

MedQ Opportunity Corporation (a 501(c)3) was formed to evaluate medical device ideas initially to determine if the idea has potential and if so, to further evaluate the medical device for development, manufacturing, and sales potential. Those ideas may come from internal or external sources.

The company will not request funding for the initial evaluation and for the further evaluation if undertaken. However, if expenses are generated during the initial evaluation and with the approval of the idea generator, the company may ask for reimbursement of reasonable expense.

Reimbursable expenses will be documented and agreed to in advance.

Purposes of the corporation include:

  • Purpose one: Review Potential Medical Device Product Ideas
  • Purpose two: Generate Medical Device Product Ideas;
  • Purpose three: Evaluate those ideas for development;
  • Purpose four: Provide a detailed report/analysis of the product production possibility

Merck

MEMBER SINCE 2015

We aspire to be the premier research-intensive biopharmaceutical company​.
Our purpose: We use the power of leading-edge science to save and improve lives around the world
For more than 130 years, we have brought hope to humanity through the development of important medicines and vaccines. We aspire to be the premier research-intensive biopharmaceutical company in the world — and today, we are at the forefront of research to deliver innovative health solutions that advance the prevention and treatment of diseases in people and animals. We foster a diverse and inclusive global workforce and operate responsibly every day to enable a safe, sustainable and healthy future for all people and communities.

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Missouri Breaks Industries

Missouri Breaks Industries Research Inc. is a small Indian-owned business located on the Cheyenne River Sioux Reservation in South Dakota.  It is centrally located in and primarily works and employs people from a Federal Labor Surplus area – specifically the Federal Indian Reservations of North and South Dakota and is HUB certified. The Missouri Breaks Industries Research Inc. is qualified under 25 USC 47 as a “Buy Indian” business to conduct research of medical problems and to disseminate information learned through this research to health care providers, tribal leaders, and community members.

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Mount Marty University

Mount Marty University, located in Southeast South Dakota, offers an online master’s in biotechnology and a graduate certificate in biotechnology management. These programs prepare future leaders and executives in a rapidly growing industry. They are unique in their focus on leadership and communication across the science and business of biotechnology – and they are one-of-a-kind as the only graduate programs to be taught entirely by current biotechnology executives.

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Myer-Hall Machine Works

At Myer-Hall Machine Works, we believe you deserve advanced, quality equipment designed to meet your needs and position your company at the forefront of your industry.
Owned and operated by degreed engineers who understand what it takes to keep up with a shifting technological landscape, Myer-Hall Machine Works collaborates with you to build customized machines that keep you competitive.
Our team is dedicated to making the process of innovation easy and convenient. We work with you to create a seamless transition from the old to the new. With experience in every major automation platform including Allen-Bradley, Siemens, Schneider, and Omron, we can ensure your new automations blend effortlessly within your larger automation system.
 

Norofert Ag

Norofert is the main producer of organic inputs for agriculture in Romania, founded in 2000.
Norofert has constantly evolved, from an importer and distributor of fertilizers for agriculture, to the most important Romanian producer of inputs and phytosanitary products for organic agriculture. It currently operates in 3 main business lines: research, production and marketing of inputs for organic farming, organic farming and grain trading. In addition to its standard range of ecological products, Norofert is known for the production of customized ecological inputs, adapted to the specifics of the soil, atmospheric conditions and the type of culture practiced.

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Northern State University

MEMBER SINCE 2007

Located in Aberdeen and founded in 1901, Northern State University is a public institution characterized by outstanding instruction, extraordinary community relations, and unparalleled extracurricular opportunities. It has a total undergraduate enrollment of 3,600 with representation from 42 states and 42 foreign countries and the campus size is 72 acres.

Novartis

Novartis is a Swiss multinational pharmaceutical company based in Basel, Switzerland. It is one of the largest pharmaceutical companies by both market capitalization and sales.

We reimagine medicine to improve and extend people's lives. We use innovative science and technology to address some of society's most challenging healthcare issues. We discover and develop breakthrough treatments and find new ways to deliver them to as many people as possible

OmegaQuant, LLC

OmegaQuant, LLC is the exclusive provider of the HS-Omega-3 Index®. This novel blood test was developed to measure the level of omega-3 fatty acids (EPA and DHA) in red blood cell membranes. The risk for sudden cardiac death is reduced by up to 90% in individuals with the highest HS-Omega-3 Index®, and there is growing evidence for an association between omega-3 biostatus and other conditions such as dry eye, macular degeneration, dementia, depression, joint health, etc.

Ovis

MEMBER SINCE 2020

Ovis Sheep is a specialized sheep production facility that offers specific pathogen free sheep for research purposes in the biomedical and veterinary sciences. Pathogen reduction and the elimination of specific pathogens from the sheep flock are primary goals of Ovis.

The specific pathogen free flock was developed and is maintained so that the sheep are not infected by commonly carried pathogens found in most typical sheep flocks.

These specific pathogens may interfere with research results, reduce the sheep’s health and lifespan, affect the sheep’s ability to produce safe and high-quality biological products, and could potentially be transmitted to and affect the health of human handlers.

Pfizer

MEMBER SINCE 2007

Breakthroughs That Change Patients' Lives: Pfizer is a leading research-based biopharmaceutical company. We apply science and our global resources to deliver innovative therapies that extend and significantly improve lives. Every day, Pfizer colleagues work across developed and emerging markets to advance wellness, prevention, treatments and cures that challenge the most feared diseases of our time.

Phylloceuticals, LLC

STARTUP • 2025

Phylloceuticals is a unique technology company perfectly positioned to bring therapeutics to market for patients, healthcare systems, and our nation’s national security needs.

We do it in a way that is safer, faster, and cheaper than anyone else. Phylloceutical's technology is a reduced-risk, clean-profile solution.

We are driven by enabling strong profit margins while becoming the first pharmaceutical firm to meet high standards for social impact.

All while broadening access to critical therapeutics across the globe.

Pioneer BioTech

MEMBER SINCE 2020

Pioneer BioTech is a hard working team of scientists from South Dakota State University. After founding the company in 2020, Matthew Cole spread news of his vision to a few close friends, and thus, the research to improve sustainable agriculture began.

PlantCatalyst

PlantCatalyst®
A Natural Plant Growth Alternative

Invented more than 40 years ago by award winninag chemist, Dr. John W. Willard (PhD Purdue University), PlantCatalyst® is a water additive that boosts a plant’s ability to more fully absorb and utilize nutrients. This proprietary blend improves the uptake and assimilation of nutrients into plant cells so that they can devote more energy to growing and flourishing.

When used as directed PlantCatalyst® will help the plants better utilize the nutrients and water in the soil and/or whatever growing medium is being used. Not typically used as a complete nutrient replacement regimen, PlantCatalyst® will allow growers to maximize their nutrient regimen and significantly reduce the need to add more fertilizers and other nutrients. As a result, growers can significantly reduce the amount of fertilizer and other nutrients needed saving time and money, while boosting crop growth and yield.

In this way, PlantCatalyst® provides farmers and gardeners alike with a safe, natural and completely non-toxic way to increase yields while limiting the amount of nitrogen-based fertilizer needed, keeping your wallet fuller and the planet safer at the same time.

Poet

MEMBER SINCE 2010

POET, one of the world's largest ethanol producers, is a leader in biorefining through its efficient, vertically integrated approach to production. The 25-year-old company has a production capacity in excess of 1.6 billion gallons of ethanol and 9 billion pounds of high-protein animal feed annually from its network of 27 production facilities. POET also operates a pilot-scale cellulosic bio-ethanol plant, which uses corn cobs, leaves, husk and some stalk as feedstock, and expects to commercialize the process in Emmetsburg, Iowa through its joint venture with Royal DSM.

A Vision and Beyond: The Story of POET

Porchlight

PorchLight is a Midwest talent recruitment firm that partners with rural communities to prepare for the 21st Century workforce. We believe that you should be able to work big and live small no matter where you choose to call home.
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Public Affairs Co. (PhRMA)

MEMBER SINCE 2007

PhRMA, the Pharmaceutical Research and Manufacturers of America, represents the country's leading biopharmaceutical researchers and biotechnology companies. The members are committed to finding tomorrow's cures and treatments for some of the most serious diseases such as Cancer, Alzheimer's Disease, Cystic Fibrosis and Parkinson's.

Research Park at SDSU

MEMBER SINCE 2014

The Research Park at South Dakota State University and Innovation Center are managed by the SDSU Growth Partnership, Ltd. The Board of Directors delivers both unique insight and experience to the management of these entities. Their leadership has placed South Dakota State University in a strong position moving into the future. They understand the importance of how university talent can assist the economic growth of business and industry in the region.

Ridgeline Fabrication

Stainless steel and custom fabrication based in Spearfish, South Dakota.

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Risty Benefits

Risty Benefits is an independent insurance agency specializing in employee benefits for businesses and individuals in South Dakota and the tri-state area. They offer health, life, and long-term care insurance, retirement plans, and support services like compliance guidance and benefits administration.

RTI., LLC - RESEARCH-TECHNOLOGY-INNOVATION

MEMBER SINCE 2007

RTI, LLC (RTI) is a leading veterinary contract research organization and microbiology laboratory. Established in 1994, the company provides clientele with quality services and support, with expertise in vaccinology, microbiology, virology, and nutrition. Specializing in biologicals for food animals, RTI's clients include several Fortune 500 companies, as well as, multi-nationals, mid-size, and start-up biotech firms. With RTI's diagnostic reagent area, they offer extensive array of monoclonal antibodies for laboratory needs. The company's research team strives to stay at the forefront of animal heath advances and improvements while demonstrating leadership in the field of veterinary research and biotechnology.

SAB Biotherapeutics

MEMBER SINCE 2007

SAB BIO is a clinical-stage biopharmaceutical company working to treat and prevent immune and autoimmune disorders. Founded in 2014 and traded on NASDAQ (SABS) since 2021, SAB BIO’s innovative genetic engineering platform produces human, multi-targeted, high-potency immunoglobulins (IgGs), without the need for human donors or convalescent plasma. The science behind the platform originated in 1998, and the company began its first clinical trials in 2017.

To date, SAB BIO has conducted seven clinical trials that have dosed 700 individuals across multiple therapeutic areas. The safety and immunogenicity database for these trials shows zero patients with serum sickness or neutralizing anti-drug antibodies, which suggests an improved safety profile over other therapies.

The company’s lead investigational candidate, SAB-142, is a novel, potentially disease-modifying therapy for type 1 diabetes (T1D). As a potentially redosable human antibody, rather than an insulin or chronic therapy, SAB-142 is being investigated for its ability to delay clinical onset and progression of T1D.

Sanford Health

MEMBER SINCE 2007

Sanford Health, one of the largest health systems in the United States, is dedicated to the integrated delivery of health care, genomic medicine, senior care and services, global clinics, research and affordable insurance. Headquartered in Sioux Falls, South Dakota, the organization includes 44 hospitals, 1,400 physicians and more than 200 Good Samaritan Society senior care locations in 26 states and nine countries.

Sanford Underground Research Facility (SURF)

The Sanford Underground Research Facility, or Sanford Lab, is an underground laboratory in Lead, South Dakota. The deepest underground laboratory in the United States, it houses multiple experiments in areas such as dark matter and neutrino physics research, biology, geology and engineering.


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Sioux Falls Development Foundation

MEMBER SINCE 2007

The Sioux Falls Development Foundation works to encourage local business expansion and attract new business and talent to the region. By promoting the unique business advantages of a Sioux Falls location and helping innovative firms to network for rapid business growth, the Development Foundation has been particularly helpful to the biotech industry in the area.

SoDak Solutions

SoDak Solutions is a consulting service focused on assisting in the navigation from early-stage research to product development. We help our clients develop their products to be positioned with investors or other strategic partners. We pride ourselves on providing services that meet the specific needs of our clients.

South Dakota EPSCoR


The National Science Foundation (NSF) created the Established Program to Stimulate Competitive Research (EPSCoR) and South Dakota was one of the initial jurisdictions to join the program, starting in 1987. The EPSCoR program is designed to assist states to establish a self-sustaining academic research enterprise with the competitive capability that will contribute to the states' economic viability and development. SD EPSCoR's mission is to strengthen research and education in science, technology, engineering and mathematics (STEM) across South Dakota to increase science literacy and drive science-based economic development. SD EPSCoR helps build South Dakota's research infrastructure and increases its capacity to successfully compete for federal funding.

South Dakota First Capital

South Dakota First Capital Group is an emerging investment firm that seeks to invest in clever, gritty, and charismatic team's working on compelling businesses in South Dakota and the Upper Midwest of the United States. The firm further leverages the strong business, governmental affairs, and scientific/technical expertise of its Partners to create dynamic opportunities for its portfolio companies.

South Dakota Governor's Office of Economic Development (GOED)

The Governor's Office of Economic Development expands primary job opportunities in South Dakota by retaining existing businesses, fostering new businesses and recruiting out-of-state companies. Efforts are focused on six key industries, including biosciences. We work with local EDCs to expand and diversify the state's economy, as well as administer a variety of financing programs.

South Dakota Innovation Partners

MEMBER SINCE 2009

Innovation Partners is not a traditional venture capital firm – the partners focus on technology commercialization beginning at the earliest stage of development – conceptualization. Research partners have been successful working with Innovation Partners from invention disclosure, through initial scale-up steps and establishing industrial scale operations. Over the last few years, the partners' projects have generated over $200 million in follow-on capital, 150 new jobs, and $100 million in annual recurring value. Innovation Partners does not stop at simply providing investment capital, but rather focuses its start-up talent and experience on de-risking key development areas, such as intellectual property, technology, market, people, and finance.

South Dakota Mines

MEMBER SINCE 2008

South Dakota Mines is committed to excellence in science and engineering academics and research, and to developing the next generation of leaders and problem-solvers. The university offers a wide array of bachelors, masters and doctoral degrees.

History
Founded in 1885 to provide instruction in the region’s primary industry, mining, today South Dakota Mines has evolved into one of the leading science and engineering universities in the region.
University History | University Leadership

Why South Dakota Mines
Located in Rapid City, in the beautiful Black Hills of South Dakota, South Dakota Mines offers a rigorous academic experience, supported by small class sizes, committed faculty members, and many student development programs and organizations. We’re known for:

  • STEM Academics

  • Personal Attention

  • Outstanding Internship Opportunities

  • Great Value

  • Our wonderful location: the Rushmore Region

South Dakota Soybean Checkoff

Partners in Support of Soybean Farmers
Two distinct South Dakota Soybean groups — the South Dakota Soybean Research & Promotion Council (SDSRPC) and the South Dakota Soybean Association (SDSA) — are sister organizations designed to support South Dakota soybean growers. The two groups are funded and governed separately and have unique goals and missions. The groups do share administrative resources and are united in the overarching goal of helping South Dakota soybean growers thrive.

We’re working together and growing together to give the next generation every advantage. The South Dakota Soybean Research & Promotion Council represents the farmers of South Dakota. We’re joining forces to generate cutting-edge technologies, explore emerging global markets and enhance the future for South Dakota soybean growers. Together, we’re generation soy.

South Dakota State University

MEMBER SINCE 2007

South Dakota State University is the state's largest and most comprehensive university. It is recognized by the Carnegie Foundation for the Advancement of Teaching as a research university/high activity. Enrollment at SDSU is nearly 13,000 students from throughout South Dakota, all 50 states and 52 countries. The university offers 12 Ph.D. programs and two professional doctoral programs. SDSU has a contiguous campus of 272 acres in Brookings and nearly 15,000 acres in seven locations from Buffalo to Beresford for agricultural research and demonstrations. Biotechnology research education programs include agricultural crops, veterinary and biomedical sciences, industrial biotechnology, pharmaceutical sciences, livestock, bioenergy and other fields.

Startup Sioux Falls

MEMBER SINCE 2011

An ecosystem organization that empowers founders by offering resources to network, launch, and grow their ventures. If you have ever aspired to launch something of your own, we want you to join our community. Start with Startup Sioux Falls.
Learn more about Startup Sioux Falls at startupsiouxfalls.com.

Sunbird Software

Sunbird Software is changing the way data centers are being managed. With a focus on real user scenarios for real customer problems, we help data center operators manage tasks and processes faster and more efficient than ever before, while saving costs and improving availability. We strive to eliminate the complexity they have been forced to accept from point tools and home grown applications, removing the dependency on emails and spreadsheets to transform the delivery of data center services. Sunbird delivers on this commitment with unexpected simplicity through products that are easy to find, buy, deploy, use, and maintain. Our solutions are rooted in our deep connections with our customers who share best practices and participate in our user groups and product development process.

University of South Dakota

MEMBER SINCE 2007

The University of South Dakota is a vibrant setting of innovation artistry and discovery, with research and creative activity opportunities in all disciplines across campus. USD researchers collaborate with industry professionals to bring new technologies to market as well as carrying out fundamental research in order to elucidate physical processes, improve human health, and protect the environment. In addition to individual research, the university hosts multi-disciplinary competitive research centers that foster academic excellence and spur economic growth. Biomedical engineering, chemistry, and physics are the main pillars of USD’s materials research; key research strengths and facilities within this area include the Center for Ultra-low Background Experiments in Dakotas (CUBED), Graduate Education and Applied Research Center (GEAR), and Center for Security Printing and Anti-Counterfeiting Technologies (SPACT). USD is also home to the state's only medical school. Sanford School of Medicine faculty members teach students the latest techniques and skills for a career in biomedical research. Critical biomedical research areas include anatomy and structural biology, cancer biology, immunology, cardiovascular sciences, microbiology, neuroscience, rural healthcare, pharmacology and physiology, among others. Key research groups and facilities include: South Dakota Biomedical Research Infrastructure Network (BRIN), Neuroscience & Nanotechnology Network (USD-N3), Center for Brain & Behavior Research (CBBRe) and USD’s two biomedical cores: Behavioral Core and Physiology Core.

USD Discovery District

MEMBER SINCE 2015

The USD Discovery District is a resource to help grow companies in South Dakota and connect universities with innovation-driven businesses. The Master Plan envisions a dynamic environment for students, researchers and entrepreneurs developing new innovations. The 80-acre site includes the Graduate Education and Applied Research (GEAR) Center that provides a physical location for both private sector and university research activities, including USD's Biomedical Engineering Program (BME). At 22,000 square feet, the Center's specialized research suites, equipment and technical staff support public and private sector research activities. An Aseptic GMP Production and Training Center provides pilot-scale cGMP and BME faculty and students are actively engaged in industry collaborations to advance the frontiers of biomedical science and engineering bring new products to market.

Value Visor

Value Visor is a boutique valuation and M&A firm located in South Dakota, with South Dakota work ethic and South Dakota Values.

Learn more

Vertex

MEMBER SINCE 2017

Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious and life-threatening diseases.We discove

red and developed the first medicines to treat the underlying cause of cystic fibrosis (CF), a rare, life-threatening genetic disease. In addition to clinical development programs in CF, Vertex has more than a dozen ongoing research programs focused on the underlying mechanisms of other serious diseases. Founded in 1989 in Cambridge, Massachusetts, our corporate headquarters is now located in Boston's Innovation District, and our international headquarters is in London, United Kingdom. We currently employ approximately 2,500 people in the United States, Europe, Canada, Australia and Latin America with nearly two-thirds of our staff dedicated to research and development.

Warhorse Design LLC

STARTUP • 2025


More information coming soon.

Wohope Wowachantognaka Mashitunka owanza

STARTUP • 2025

The Sicangu Nation Employment & Training Program is a public law 102-477 program which consolidates funds from the Workforce Innovation & Opportunity Act, General Assistance and the Native Employment Works Program.
The Sicangu Nation Employment & Training Program has the flexibility to allow the staff to be more creative when developing employability plans and working with clients.
Our Mission is to give our Native people the access to employment opportunities, the basic skills needed to be successful on the job and the resources to strengthen their families.
Our goal is to increase the ability of participants to obtain employment by enhancing work skills, provide real value to agencies, organizations and communities by providing worksite placements and promote economic opportunities for participants.